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Lancet began in 1823 as a free, global weekly medical journal. Since its inception, the journal has strived to make science widely accessible so that pharmaceuticals can benefit and transform society, positively impacting people's lives. Throughout the past two centuries, Lancet has sought to address important issues in their community, initiating debates, contextualizing science, and influencing decision-makers worldwide. They have evolved as a group of journals but maintain the belief that medicine should serve society, knowledge should transform society, and the best science should lead to improved lives. They set exceptionally high standards, carefully selecting only the most outstanding scientific papers based on their quality and impact.